Authors: Benoit Michot MSc, PhD ,Gozde Yildirim MSc, Lina Alzahrani BDS, MSc, DMSc, Jennifer L. Gibbs DDS, MSc, PhD.
Comparison of the Neurocompatibility of 3 Different Classes of Endodontic Materials, Resin-Based (AH-Plus), Calcium Silicate (BC-Sealer), and Hydrogel-Based (Odne™Fill)
Journal of Endodontics
Postoperative pain after root canal therapy can stem from chemical toxicity and tissue damage caused by the obturation material, making material selection crucial for minimizing nerve injury. This study compares the neurocompatibility of three endodontic sealers—resin-based, bioceramic, and hydrogel-based OdneFill. Using in-vitro models of human and mouse sensory neurons, researchers found that OdneFill in its solid form exhibited the highest neurocompatibility, while the bioceramic sealer and liquid OdneFill showed intermediate compatibility. The resin-based sealer demonstrated the least favorable effects. These findings provide new insights into the relationship between sealers and neuronal health, highlighting OdneFill’s low neurotoxicity and its potential to reduce inflammatory pain and improve patient outcomes compared to conventional sealers.
About the author
Benoit Michot, MSc, PhD, is a researcher in the Department of Restorative Dentistry and Biomaterials Sciences at the Harvard School of Dental Medicine in Boston, MA, USA. His work focuses on advancing materials and techniques in restorative dentistry, with a particular interest in endodontics and biomaterials. Dr. Michot has contributed to several peer-reviewed publications and continues to explore innovative solutions to improve clinical outcomes in dental care.